Cabanga nje ukuthi uyakwazi ukunikeza umzimba wakho uhlobo lwesivikelo ngaphambi kokubhekana namaqiniso anzima okwelashwa komdlavuza. Sekuyiminyaka, i-chemotherapy iyithuluzi elibalulekile lokusindisa izimpilo, kodwa iza nomthwalo osindayo wemiphumela emibi, kanti i-peripheral neuropathy ingenye yezinkinga zekhanda ezivame kakhulu nezinzima ezigulini ukuzilawula.
Muva nje, isayensi igxile ku-psilocybin, i-compound etholakala ezinhlotsheni ezithile zamakhowe futhi evame ukuhlotshaniswa nokuhlangenwe nakho kwe-psychedelic. Okumangazayo ukuthi, ngale kokusetshenziswa kwayo empilweni yengqondo, le compound ibonakala inethalente elifihliwe lokuvikela izinzwa , isebenza cishe njengomjovo ovimbela umonakalo ukuthi ungenzeki, kunokuba izame ukuwulungisa lapho sekuphuze kakhulu.
Inkinga ye-peripheral neuropathy
Uma sikhuluma nge-chemotherapy-induced neuropathy (CIPN), sibhekisela kulokho kuqaqamba okuqhubekayo, ukungazweli, noma ukuzwela okukhulu emakhazeni okuthinta abangaphezu kuka-60% balabo abathola imithi esekelwe ku-platinum. Akusikho nje ukungakhululeki okudlulayo; ezimweni eziningi, izimpawu zihlala iminyaka eminingi, zingabekezeleleki kangangokuthi odokotela baphoqeleka ukwehlisa umthamo wokwelashwa noma, ezimweni ezimbi kakhulu, bawuyeke ngokuphelele, okubeka engcupheni ukulwa nesimila.
I-psilocybin ivikela kanjani imizwa?
Ithimba lochwepheshe e-MD Anderson Cancer Center eTexas lithole ukuthi isihluthulelo sisemandleni. Ama-neuron angamaseli amade kakhulu futhi adinga i-mitochondria (izindawo zamandla zeseli) ukuze ahambise amandla emaphethelweni awo, njengezandla noma izinyawo. Ukwelashwa ngamakhemikhali empeleni kuyawunqamula lo mthombo wamandla , okubangela ukuba imizwa ife ngenxa yendlala.
Yilapho i-psilocybin ingena khona. Ngokusebenzisa i- 5-HT2A serotonin receptor , le nhlanganisela igcina ukugeleza kwe-mitochondria ezindaweni ezikude kakhulu ze-nerve. Ngamanye amazwi, iqinisekisa ukuthi amandla afinyelela lapho eya khona nokuthi i-nerve fiber ayonakali. Into emangalisa kakhulu ukuthi lo mphumela awuphazamisi ukusebenza kahle komuthi ngokumelene nomdlavuza; uvikela uhlelo lwezinzwa ngaphandle kokunikeza isimila amandla.
Ngale kwemibono engekho
Abantu abaningi bacabanga ukuthi i-psilocybin idinga uhambo lwe-psychedelic ukuze isebenze kahle, kodwa idatha iphakamisa okuhlukile. Kumagundane, amakhemikhali avuselela i-receptor efanayo kodwa angavezi imibono eyeqisayo aboniswe ukuthi ahlinzeka ngesivikelo esifanayo. Lezi yizindaba ezinhle kakhulu, njengoba kungenza kube lula kakhulu ukusetshenziswa kwayo ezindaweni zokwelapha zangempela ngaphandle kokudinga iziguli ukuthi zenze okuhlangenwe nakho okukhulu kwezinzwa.
- Imithi efakazelwe: Kuye kwabonakala ukuthi kusebenza kahle ngokumelene ne-cisplatin, i-paclitaxel, kanye ne-docetaxel.
- Isikhathi: Isivikelo sagcinwa ngemuva kwemijikelezo eyisithupha yokwelashwa kanye nezinyanga eziyisishiyagalombili zokulandelwa kwamamodeli ezilwane.
- Umshini: Akulungisi inzwa eyonakele, kodwa kuvimbela umonakalo ukuthi ungenzeki kwasekuqaleni.
Umthelela empilweni yengqondo kanye nobuhlungu
Asikwazi ukukhohlwa ukuthi umdlavuza awuhlaseli umzimba kuphela kodwa nengqondo. I-Psilocybin, enikezwa ngezikhathi zeqembu ngokusekelwa kokwelapha, iboniswe iyindlela enamandla yokwelapha ukucindezeleka kweziguli ezinomdlavuza, ikakhulukazi labo abangaphenduli emithini yokucindezeleka evamile. Ngokunciphisa ukukhathazeka nokucindezeleka ngokomzwelo, kwakheka umjikelezo omuhle: isiguli esinomoya othuthukisiwe sivame ukubona ubuhlungu obungokomzimba kancane kakhulu , sithuthukisa kakhulu ikhwalithi yaso yokuphila.
Indlela eya ekwelashweni kobuntu
Nakuba imiphumela emagundwini ithembisa futhi indlela efanayo yokuthutha i-mitochondrial ibonwe ezicutshini zabantu, kusadingeka siqaphele. Ukuhlolwa kwe-NeuroGuard (isigaba sesi-2) kuyaqhubeka okwamanje , kufunwa ukuthola ukuthi ngabe ukunikeza i-psilocybin ngaphambi komjikelezo ngamunye we-chemotherapy kuphephile yini nokuthi ngabe kuyayinciphisa ngempela i-neuropathy kubantu. Kuhlolwa imithamo ehlukene, kufaka phakathi imithamo ephansi engabangeli imiphumela ebonakalayo, ukuthola ibhalansi eqondile phakathi kokuphepha nokusebenza kahle.
Isayensi iqhubekela phambili emodelini egxile esigulini kanye nokugxila ekwenzeni ukwelashwa kufinyeleleke kalula. Amathuba okusebenzisa lezi zindlela zokwelapha ezindaweni zamaqembu anganciphisa izindleko futhi avimbele lezi zinto ezintsha ukuthi zingagcini kubantu abaphezulu, okuvumela abantu abaningi ukuba bagweme ubuhlungu obungapheli obubangelwa ukwelashwa kwabo komdlavuza.
Lokhu kuthuthuka kuphawula ushintsho oluyisisekelo ngokuphatha i-neuropathy njengokulahlekelwa okungavinjelwa kokumelana nezinzwa. Ngakho-ke i-Psilocybin ivela njengethuluzi eliguquguqukayo, ngokusebenzisa i-neuronal plasticity nokuqinisekisa ukutholakala kwamandla eseli, elingashintsha ulwazi lwezinkulungwane zeziguli, libavumele ukuthi baqedele ukwelashwa kwabo komdlavuza ngokuhlupheka okuncane ngokomzimba nangokwengqondo.